Manchester United will be aiming to bounce back from a dismal European night as they travel to Southampton, who have failed to score in three of their five Premier League games so far.
The latest blank came last time out away to West Bromwich Albion in a game of few chances, but having looked the more likely to break the deadlock it will have been frustrating for manager Ronald Koeman that his side did not manage to come away with all three points. Dusan Tadic provided their biggest threat, and he at least appears to have returned to the kind of form that earned him so many plaudits in the early months of last term.
If he can hit the mark here with his creative ability, Graziano Pelle has the ability to more than hold his own against the United back four, while it may be worth including Shane Long in the starting XI due to his relentless energy and the pressure that he puts on opposition defences. Meanwhile, Sadio Mane has the opportunity to show just why he was the subject of interest from the Red Devils in the latter weeks of the transfer window.
What should have been a cause for celebration as they marked their return to European competition after a year away turned into an evening to forget for Manchester United. They were on top for the majority of the game against PSV Eindhoven and went ahead through Memphis Depay, but they were eventually left to reflect on a defeat which was made much worse by a very serious injury to Luke Shaw, which robs him of the chance to face his former club here.
The game also saw a first start for Anthony Martial, who made quite the introduction with a sublime solo goal to ensure victory over arch rivals Liverpool last weekend. The injection of pace brought to the table by Ashley Young turned the game in their favour as a dull first half was soon forgotten. It means United now lie in third place, and with David De Gea back in goal, they are nearly at full-strength and will expect to dictate the play on the South coast while offering more of an end product.
The home side have doubts over Gaston Ramirez, and are still definitely without injured quartet Jordy Clasie, Florin Gardos, Ryan Bertrand and Fraser Forster.
The are question marks over whether Shaw will represent United again this season, but they do at least have captain Wayne Rooney back available.