The current Premier League leaders take on the reigning champions, as Arsenal make the trip to Old Trafford for a meeting with Manchester United.
Although they remain eight points behind their opponents, Man Utd have began to turn the corner recently after their fortunate win over Stoke City. A comfortable win at Fulham followed before their wastefulness in Spain left them with work still to do if they are to guarantee their place in the knockout stages, but they are at least beginning to look more potent in attack.
Arsenal pulled off a brilliant result away to Borussia Dortmund in the week which should have them high on confidence going into this game, despite their woeful recent record away to Man Utd. The previous two results have seen the Gunners go a long way to silencing their doubters, although there are still some concerns over the amount of depth in a squad that has been ravaged by injury.
Man Utd will be waiting on the fitness of Jonny Evans, Rafael da Silva and Michael Carrick, who all missed the draw with Real Sociedad, while Robin van Persie will again be aiming to score against his former club.
Mathieu Flamini and Theo Walcott could both return for Arsenal, but the injury list remains lengthy, with Lukas Podolski, Alex Oxlade-Chamberlain, Abou Diaby, Yaya Sanogo and Serge Gnabry all missing.
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