Chelsea have the chance to make the lead at the top of the Premier League become an even more commanding one as they take on Arsenal, who will be keen to avoid another humiliation at Stamford Bridge.
Going into the weekend, the Blues had already opened up a lead of five points over Manchester City and are six above Arsenal, thanks to a start to the season which has seen them carry the aura of potential title winners, and their last Premier League outing against Aston Villa saw them continue in that vein with an easy 3-0 victory.
They then went on to triumph in Lisbon in the Champions League to move into a dominant looking position already in Group G, in a game which was far more one-sided than the 1-0 scoreline suggests. Diego Costa started that game and is likely to begin this one, despite an ongoing problem which leaves him unable to fully train.
Manager Jose Mourinho has never lost to Arsenal as a manager, and it would come as a surprise should that run be ended here, particularly with the manner in which the Gunners have failed to live with the top teams on their travels, something which was again in evidence just weeks ago when they lost to Borussia Dortmund in the Champions League.
They responded well in that competition to thrash Galatasaray on Wednesday, with Danny Welbeck claiming a fine hat-trick, a game which came after a frustrating draw with Tottenham in the North London derby, which means they have drawn four of their opening six league matches.
The first target for Arsenal will be to survive the opening exchanges without conceding a goal, with their 6-0 defeat in West London last season still not completely erased from their minds.
Didier Drogba misses out for Chelsea with an ankle injury, and Ramires is also unavailable with a groin problem.
Arsenal are likely to have Nacho Monreal back from injury, but Mikel Arteta and Aaron Ramsey remain out along with Theo Walcott, Mathieu Debuchy and Olivier Giroud.
See what the expert tipsters at OLBG are tipping on Chelsea