Arsenal will seal a place in the knockout stages of the Champions League if they can see off Anderlecht at the Emirates Stadium and Borussia Dortmund beat Galatasaray in the other match in Group D.
There was much concern just minutes from the end of the reverse fixture in Belgium as Arsenal trailed 1-0, but two goals in the dying minutes secured a dramatic – and crucial – three points, which leave them five points ahead of the bottom two in the group.
They will still harbour hopes of catching Dortmund for top spot, but should qualification be ensured here, Arsene Wenger can afford to relax to a degree, with his hopes of bridging the gap in the Premier League to leaders Chelsea also very much a priority. The Gunners have at least earned successive wins domestically for the first time this season, with Alexis Sanchez starring again in the 3-0 triumph over lowly Burnley on Saturday.
The best Anderlecht can realistically hope for is third spot and a place in the Europa League, but they played well for large parts in the reverse game and were visibly shell-shocked by the what happened at the end. They still sit atop the Belgian league, but have only won one of their last five matches.
The home side still have a number of injuries, with Jack Wilshere added to the list of absentees due to illness. Theo Walcott could make his first start after injury.