Manchester United will be intent on not dropping any more points as they come up against a Crystal Palace side which has slipped to three defeats in four games.
Manager Louis van Gaal was visibly and audibly downbeat after he emerged on the losing side after his first Manchester derby, which left the club in mid-table with only 13 points from a possible 30.
The sending off of Chris Smalling had a large bearing on the result, and his resultant absence here means United have another crisis at the heart of their defence. A strong finish at the Etihad with 10 men came as no consolation.
The visitors now find themselves out of the drop zone by virtue of scoring more goals this season than Leicester City, and on Monday they slid to a potentially costly home reverse to fellow strugglers Sunderland.
It was a game where the Eagles lacked end product, but looked the more likely team to win it at one stage after a strong opening to the second period. Here, they will be hoping that Yannick Bolasie in particular can provide more quality as his pace could give the home backline some major problems.
Smalling misses out for United alongside fellow defenders Marcos Rojo, Jonathan Evans and Phil Jones. This game could also come too soon for Radamel Falcao.
Palace have no injuries, but are without captain Mile Jedinak due to suspension, and Wilfried Zaha cannot play against his parent club, so Jason Puncheon is likely to take his place.
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