Liverpool will be determined to avoid a repeat of their recent thrashing by Real Madrid as they face them again in Champions League Group B; this time at the Bernabeu.
The manner in which the Reds lost so comfortably against the European champions at Anfield was alarming, and confirmed that there is a massive gulf between the two sides regarding where they are in their development.
Cristiano Ronaldo was often unplayable, while poor defending allowed Karim Benzema to grab a brace. Liverpool must be considerably tighter at the back here to have any chance of coming away with a result, and even a draw here would go a long way to aiding their hopes of making the knockout stages.
Recent form does not offer much cause for comfort, with a formation change by manager Brendan Rodgers on Saturday at Newcastle United failing to pay dividends. There was a rare lack of an attacking threat from Liverpool as they lost to a second half strike, failing to score in the Premier League for the second game running.
The home side are in red-hot form, by contrast, and they followed up their massive El Clasico victory over Barcelona with a comprehensive win away to Granada. That result was not only their seventh success in a row, but it saw them go top of La Liga after 10 games.
Gareth Bale could return to play here after being injured for the reverse fixture, but Daniel Sturridge is likely to remain out for the visitors despite making the trip to the Spanish capital.