Arsenal will be aiming to add consistency to their repertoire for the season as they come up against a Southampton side currently six points above them in the table.
The win away to West Bromwich Albion in their last game was crucial for the Gunners, who had been coming under increasing pressure to pick up results in the Premier League, having laboured to the extent that a tilt at the title already looks highly unlikely.
Danny Welbeck continued his strong scoring start to life as an Arsenal player, but the headlines at the Hawthorns were somewhat needlessly dominated by a handful of supporters unfurling a banner which called for manager Arsene Wenger to leave his post.
Having won eight and drawn one of their previous 10 league games, the comprehensive manner of Southampton’s loss to champions Man City on Sunday must have come as a shock to the system, as they came up against a side in top form.
However, it would be unfair to write off their brilliant start as an anomaly off the back of that one result, and the Saints still possess the quality to trouble their more established opponents, after winning at the Emirates Stadium in the Capital One Cup in September.
Damian Martinez is likely to continue in goal for Arsenal with Wojciech Szczesny still absent. Mikel Arteta, Kieran Gibbs, Nacho Monreal and Alex Oxlade-Chamberlain are all major doubts.
Southampton are set to give a recall to Jack Cork due to an injury to Morgan Schneiderlin, while Jay Rodriguez and James Ward-Prowse are both edging closer to a return.
See what the expert tipsters at OLBG are tipping on Arsenal