Even then, they will be reliant on fellow strugglers Newcastle United to drop points in their game, so it is all or nothing for the Tigers, who started the season looking strong and playing in Europe. Injuries have been a hindrance, but ultimately their wastefulness in front of goal could be set to haunt them.
That was very much the case in their last game at Tottenham, where their luck was not in as they had the better of the first half without making the most of the positions they got themselves in, eventually looking toothless in their attempts to claw back the deficit in what turned out to be another fruitless afternoon.
There is less riding on this for Man Utd, but manager Louis van Gaal will respect the occasion by fielding a strong team, and he will be keen to end the season with a victory having seen his side struggle for results in recent weeks. An unfortunate Tyler Blackett own goal against rivals Arsenal added to that run.
This could be the final game for the club for strikers Radamel Falcao and Robin van Persie, who have underperformed considerably this term. Meanwhile, goalkeeper David De Gea may have already had his Red Devils swansong, as he vacates his position for Victor Valdes here.
Mohamed Diame is likely to be missing again for Hull along with Robert Snodgrass, while Jake Livermore is still suspended by the club.
The visitors have captain Wayne Rooney back after his recovery from a dead leg, but Michael Carrick is absent as well as defenders Jonathan Evans and Luke Shaw.