DM- Bastian Schweinsteiger
The German has come on on the hour-mark in both games so far this season, but van Gaal may be willing to give him his first start for the club to allow 34-year-old Michael Carrick to have a rest.
DM- Morgan Schneiderlin
There is a lot of anticipation surrounding how the two holding midfielders will play alongside each other, and while we have had glimpses so far, this game will be the first real indication.
RAM- Juan Mata
The Spaniard was gliding some wonderful passes to his teammates during the victory over Aston Villa, and if he can do that again, Brugge will be desperate to hear the final whistle.