Arsenal face a reunion with their former midfielder Alexander Hleb after being drawn against Belarussian side BATE Borisov in the Round of 32 of the Europa League.
Chelsea, who won the competition in 2013, take on Swedish side Malmo, with Scottish champions Celtic drawn to face Spanish side Valencia.
The two-legged ties will be played on 14 and 21 February 2019.
Arsenal are at home in the second leg of their tie and the game will kick off at 17:55 GMT on Thursday, 21 February to avoid a clash with Chelsea’s home game against Malmo on the same night, which kicks off at 20:00.
The Gunners and Chelsea were both seeded for the draw, meaning they host their second legs, and teams from the same city cannot play at home at the same time.
Arsenal and Chelsea both finished top of their respective groups, each winning five and drawing one of their six matches.
The Gunners are facing the same opponents they met in the group stage of last season’s competition, winning twice – 4-2 in Belarus and 6-0 in London.
Europa League last-32 draw in full
Viktoria Plzen v Dinamo Zagreb
Club Brugge v Red Bull Salzburg
Rapid Vienna v Inter Milan
Slavia Prague v Genk
Krasnodar v Bayer Leverkusen
FC Zurich v Napoli
Malmo v Chelsea
Shakhtar Donetsk v Eintracht Frankfurt
Celtic v Valencia
Rennes v Real Betis
Olympiakos v Dinamo Kiev
Lazio v Sevilla
Fenerbache v Zenit St Petersburg
Sporting Lisbon v Villarreal
Bate Borisov v Arsenal
Galatasaray v Benfica.