Man City are without Jolean Lescott and Vincent Kompany in central defence, both out with injury, so Kolo Toure and Stefan Savic will partner. The return of Carlos Tevez to the City side is approaching, and the Argentine could feature tonight, although he is set to start the tie on the bench, with Mario Balotelli and Sergio Aguero starting in attack.
For Chelsea, John Terry is set to be rested for the second game in a row, to prevent damaging his recently healed knee, so Branislav Ivanovic will continue in central defence, partnered with Gary Cahill, with Jose Bosingwa atr right-back. Up-front, Didier Drogba and Fernando Torres are set to start in attack together, along with Juan Mata.
Man City have won five of their last six Premier League ties, dropping points only in their last outing, a 1-0 defeat away to Swansea City that allowed United to usurp them at the top of the league table. That game also included the only goal City conceded in those five ties.
Chelsea meanwhile are unbeaten in all competitions under new caretaker manager Roberto Di Matteo, with three cup wins and one league win in their last Premier League clash with Stoke City.
That renewed energy for Chelsea will be needed as they try to get a result away to a Man City side that has won 24 home ties in a row, and Mancini’s men should go into this tie as favourites.